Centenarians are individuals who have reached the age of 100 years. Countless studies have been undertaken to better understand just how these individuals are aging so well. As such, a recent study has suggested that a gene found in centenarians may be the key to a longer life, as it contains heart-protective properties.Β
A Centenarian Longevity Gene
BPIFB4 is a mutant gene thatβs been identified in older adults with exceptional longevity, with previous research indicating that it has a protective effect on oneβs cardiovascular health. Heart disease is the leading cause of death worldwide, with the condition even surpassing COVID-19βs mortality rate.
If you really want to improve your longevity, then you need to focus on your heart health.Β
As previous research has indicated BPIFB4βs heart-protective properties, researchers set out to determine if the supplementation of BPIFB4 may delay the heartβs spontaneous aging.
BPIFB4 for better heart aging
For the study, published in Cardiovascular Research, researchers administered BPIFB4 to the heart cells of elderly patients with severe heart problems. The study was previously done in elderly mice, whose hearts exhibited the same alterations observed in elderly patients. The researchers found that BPIFB4 rewound the mouseβs heartβs biological clock age by the human equivalent of more than ten years.
Now back to the in vivo study. After the administration of BPIFB4 to the heart cells of elderly patients, the researchers then compared their function with those of cells from healthy individuals. The team then observed a process of cardiac rejuvenation after adding BPIFB4 to the test tube,
βThe cardiac cells of elderly heart failure patients have resumed functioning properly, proving to be more efficient in building new blood vessels.β – Monica Cattaneo, first author of the study.Β
The researchers of the study also noted that children of centenarians also carry BPIFB4, which means that theyβre likely to enjoy longevity. Thankfully, the new study indicates that the benefits ofΒ BPIFB4 wonβt only be limited to individuals who do not carry the longevity gene.
BPIFB4 as a longevity treatment?
Itβs a little too soon to tell.Β
For one, the authors point out that more studies are needed. These studies will help better determine how long the effects of the in vivo therapeutic effect will last. They also need to ascertain if repeated administrations are necessary.Β
Additionally, it has yet to be determined if the benefits observed in the mice will translate to individuals with advanced stages of heart failure.
That said, the team does believe that the new study will open up a wave of treatments that incorporate the genetics of centenarians.
βOur findings confirm the healthy mutant geneΒ can reverse the decline of heart performance in older people. We are now interested in determining if giving the protein instead of the gene can also work. Gene therapy is widely used to treat diseases caused by bad genes. However, a treatment based on a protein is safer and more viable than gene therapy.β said Professor Paolo Madeddu, Professor of Experimental Cardiovascular Medicine fromΒ Bristol Heart InstituteΒ at the University of Bristol and one of the studyβs authors.
Heart health tips
Now, we will likely have to wait to use centenarian genes to improve both our heart and longevity. However, there are a few tips you can adopt in the meantime.Β
βThe heart and blood vessel function is put at stake as we age. However, the rate at which these harmful changes occur is different among people. Smoking, alcohol, and sedentary life make theΒ aging clock faster. Whereas eating well and exercising delay the heartβs aging clock.β – Professor Paolo Madeddu
Want to know more?
As Professor Madeddu stated, exercise is one of the best ways to improve your heart health. Yet, what time of the day is best if you want to work out? Well, research has suggested that exercising in the morning is a great way to protect your heart health.
References
Cattaneo, M., Beltrami, A. P., Thomas, A. C., Spinetti, G., et al. (2023). The longevity-associated BPIFB4 gene supports cardiac function and vascularization in aging cardiomyopathy.Β Cardiovascular research, cvad008. Advance online publication. https://doi.org/10.1093/cvr/cvad008
Dossena, M., Ferrario, A., Lopardo, V., Ciaglia, E., & Puca, A. A. (2020). New Insights for BPIFB4 in Cardiovascular Therapy.Β International journal of molecular sciences,Β 21(19), 7163. https://doi.org/10.3390/ijms21197163