As you age, you mightβve started investing in anti-aging procedures to maintain a youthful appearance. These are undoubtedly effective, but there are things you can do that will improve your skin, hair, and nails from within. Not only that, but they canΒ also enhance the results of your anti-aging treatments even further. Thatβs because if youβre not nourishing your health on a cellular level, chances are the external work youβre doing wonβt be fully satisfied. Are we onto something here? In this Opinion Editorial, Leslie Kenny, Founder and CEO of Oxford Healthspan shares why she believes in spermidine.
What is spermidine?
Youβre probably thinking, what on earth is spermidine? Why donβt I know about it already? Itβs Japanβs best-kept anti-aging secret, the key word here being best-kept. Only recently has the mystery been brought to the market, and nowβ¦ no one can stop talking about it and its miraculous anti-aging benefits.
Spermidine is a potent polyamine that is present in many Japanese foods like natto and long-fermented tofu. In fact, the long-lived Okinawans ferment theirs longer than anyone else in Japan. But you can also find it in shiitake mushrooms, certain types of aged cheese, amaranth grain, and highly concentrated wheatgerm.Β
Your body naturally produces spermidine in your tissues and gut microbiome, but as with most things, you start making less and less as you age. So itβs important to make up this difference by increasing the amount you get from your diets or supplements.Β
What makes spermidine an anti-aging ingredient?
Spermidine is essential for optimal cell health, with epidemiological statistics suggesting that increasing your uptake of it may delay aging (1) (2).Β
Autophagy: the mechanism behind spermidineβs anti-aging effects
Findings show spermidine can induce autophagy (3). In other words, it kickstarts your bodyβs cellular renewal. It’s important to know that cellular renewal inevitably slows down as you age. When your cells arenβt working at their optimum level, nothing is. Everything comes down to cell health, after all.
Autophagy is how your body βcleans upβ your cells. It recycles what can still be used and gets rid of damaged, inefficient cells that canβt serve you any longer! As this process slows, telltale signs of aging begin to appear. These include wrinkles and fine lines, gray hair, hair loss, poor memory and disrupted sleep.Β
As you can imagine, itβs no use preventing aging on the outside with cosmetic treatments like botox, filler, PRP facials and facelifts without optimising your health from within. If your cells are working efficiently and regenerating properly, you should see faster recovery times from these procedures too.Β
Spermidineβs beauty benefits
Spermidine was found to act specifically on aging skin cells, increasing their elastin, collagen, and lipid production. This improves your skinβs overall barrier function and promotes a plumper, firmer appearance (4).Β Furthermore, spermidine doesnβt stop at the skin. It also benefits hair and nail health. Studies show that it potentially prolongs the first stage of the hair growth cycle and helps with hair loss (5).Β
Spermidine and weight loss
We canβt talk about autophagy and spermidine without mentioning their action as a calorie restriction mimetic (6). You see, autophagy also happens when you fast, and what does fasting do? It speeds up your metabolism and helps with weight loss. Another bonus! Weight loss is something most people struggle with in their mid-life. If youβre undertaking plastic surgery, spermidine can be very helpful, since itβs always recommended to be at your ideal weight for the best results.Β
Spermidine and stem cells: Make your vampire facial last
Stem cells are no exception to the rule. They lose their ability to divide as you age and canβt be replaced when theyβve passed a certain point. This contributes to the outward signs of aging like graying hair, fine lines and wrinkles, and brittle nails.
Keeping your stem cells healthy can slow the ageing process down and prevent that new wrinkle youβve been fretting about from forming! Not only this but having healthier stem cells can improve the effects of aesthetic procedures like PRP treatments.
A study has found that the use of polyamines, such as spermidine, can protect your cells from oxidative damage and improve their βstemnessβ – their ability to differentiate into other cells. According to the study, ββ¦these results support the idea that polyamines are able to manage both stem cell differentiation and cell oxidative damage, and therefore represent appealing tools for regenerative and cell-based applicationsβ.Β (7)
Spermidine improves the quality of the stem cells by eliminating those that are dysfunctional, as well as cellular components such as mitochondria, through autophagy and mitophagy.Β
Because these are the same stem cells that PRP isolates and injects into other parts of your body for rejuvenation, it stands to reason that having a healthier pool of stem cells to inject leads to better aesthetic outcomes. Theoretically, this should enhance the results of your PRP treatments, making it a potentially important tool for aestheticians and cosmetic practitioners as well as the customers themselves.Β
Closing remarks
Whether youβre an aesthetician, visit the skin clinic frequently, or are looking to hack your age from the inside, you might want to add spermidine – either through food or supplements – to your anti-aging roster. Weβd recommend increasing your spermidine uptake by a few months before undertaking any anti-aging treatment for the best results!